Thomas S. Scanlan

Sob-AM2 improves cognition in 5xFAD mice without altering Aβ plaque burden, suggesting TREM2-mediated microglial changes may underlie its effects.

Elunetirom and LL-340001 enhance neuronal plasticity and mitochondrial biogenesis in neuronal cultures, suggesting potential for treating depression.

This study shows that remyelination protects neurons from DLK-mediated neurodegeneration by preventing apoptosis and inflammation in a mouse model of demyelination.

This study shows thyroid hormone remodels cortical circuits in adult mice, linking metabolic state to exploratory behavior through transcriptional changes in neurons and glia.

This study shows that thyroid hormone and thyromimetics reduce disease severity and protect oligodendrocytes in EAE by decreasing myelin and axonal degeneration.