Wyatt R. Hack

Sob-AM2 improves cognition in 5xFAD mice without altering Aβ plaque burden, suggesting TREM2-mediated microglial changes may underlie its effects.

This study shows that Centella asiatica extract improves age-related cognitive decline and anxiety in mice, but effects vary by sex, dose, and administration method.

This study shows Asiatic acid improves mitochondrial function, antioxidant response, and cognitive performance in mice, with gender-specific effects on reducing amyloid plaques.

DRhQ, a CD74 inhibitor, improves cognition and mitochondrial function in 5xFAD mice but does not significantly reduce Aβ plaques or microglial activation.

This study evaluates Gardenin A's effects on A53T-α-syn mice, showing improvements in cognitive and motor function and reductions in pathological markers.