Joseph F. Quinn

Sob-AM2 improves cognition in 5xFAD mice without altering Aβ plaque burden, suggesting TREM2-mediated microglial changes may underlie its effects.

The paper identifies distinct α-synuclein strains associated with cognitive decline in Parkinson's disease and shows AI-based analysis of these strains improves clinical stratification.

This paper evaluates the polygenic risk score for Alzheimer's disease in Japanese individuals, showing its utility despite genetic differences from European populations.

This study shows Asiatic acid improves mitochondrial function, antioxidant response, and cognitive performance in mice, with gender-specific effects on reducing amyloid plaques.

DRhQ, a CD74 inhibitor, improves cognition and mitochondrial function in 5xFAD mice but does not significantly reduce Aβ plaques or microglial activation.

This paper develops a metabolomic age prediction model using CSF data from healthy humans and applies it to Alzheimer's and Parkinson's patients, finding increased prediction error in disease cohorts.

This study uses an epidemic spreading model to show that tau spreads through neuronal connections in Alzheimer's disease, with beta-amyloid accelerating this process in some brain regions.

This study compares whole hippocampus and subfield biomarkers for Alzheimer’s disease detection and prediction using multimodal MRI data, finding subiculum biomarkers improve prediction accuracy.

The paper examines the correlation between CSF sTREM2 and CSF tau levels in Parkinson’s disease and finds that sTREM2 is elevated in PD subgroups with abnormal tau but not Aβ.

Genetic correlations across 25 brain disorders (215,683 cases) reveal broad psychiatric common-variant sharing, largely distinct neurological disorders, and migraine as the only significant cross-category link.