Genetic or toxicant induced disruption of vesicular monoamine storage and global metabolic profiling in Caenorhabditis elegans
Joshua M. Bradner, Vrinda Kalia, Fion K. Lau, Monica Sharma, Meghan L. Bucher, Michelle A. Johnson, Merry Chen, Douglas Ian Walker, Dean P. Jones, Gary Wright Miller
This study investigates the effects of reduced VMAT activity in C. elegans, showing increased sensitivity to MPP+ and metabolic changes, suggesting conserved monoamine function and potential for metabolomics in disease research.
Toxicological Sciences · Jan 22, 2021Peer-reviewedNeuroscience