Circulating unacylated-ghrelin impairs hippocampal neurogenesis and memory in mice and is altered in human Parkinson’s disease dementia
Amanda K. E. Hornsby, Luke Buntwal, Maria Carla Carisi, Vanessa Valgas dos Santos, Fionnuala Johnston, Luke D. Roberts, Martina Sassi, Mathieu Méquinion, Romana Stark, Alex Reichenbach, Sarah Haas Lockie, Mario Siervo, Owain W. Howell, Alwena H. Morgan, Timothy Wells, , Jeffrey S. Davies
The paper shows that elevated circulating unacylated-ghrelin impairs hippocampal neurogenesis and memory in mice and is associated with reduced AG:UAG ratio in Parkinson’s disease dementia patients.
Cell Reports Medicine · Oct 1, 2020Peer-reviewedNeuroscience