Author

Fitzroy J. Byfield

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Organism:human· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Paul A. JanmeyiD· 3 shared Alison E. PattesoniD· 2 shared Elisabeth E. CharrieriD· 2 shared Peter A. GalieiD· 2 shared Anne Herrmann· 1 shared Anne van Oosten· 1 shared Bronson Frank· 1 shared Daniel Conway· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBiophysics

Paul A. JanmeyORCID

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4 papers

Recent·Most cited

Vimentin molecular linkages with nesprin-3 enhance nuclear deformation by cell geometric constraints

Maxx Swoger, Minh Tri Ho Thanh, Renita Saldanha, Fitzroy J. Byfield, Van Dam, Jessica Williamson, Bronson Frank, Heidi Hehnly, Daniel Conway, Alison E. Patteson

This study shows vimentin enhances nuclear deformation in polarized cells by linking to nesprin-3 and transmitting forces through the nuclear envelope.

Scientific Reports · May 21, 2026Peer-reviewedBiophysics

Role of nuclear ATPases in nuclear mechanics and cell migration through confined spaces: opposite effects of BRG1 and cohesin

Łukasz Suprewicz, Fitzroy J. Byfield, Thomas T. Dutta, Paul A. Janmey

This study shows that BRG1 stiffens isolated nuclei and inhibits cell migration through tight spaces, while cohesin softens nuclei and enhances migration.

Biophysical Journal · Feb 14, 2026Peer-reviewedBiophysics

Tissue-dependent mechanosensing by cells derived from human tumors

Kshitiz Parihar, Jonathan Nukpezah, Daniel V. Iwamoto, Katrina Cruz, Fitzroy J. Byfield, LiKang Chin, Maria E. Murray, Melissa G. Mendez, Anne van Oosten, Anne Herrmann, Elisabeth E. Charrier, Peter A. Galie, Megan Donlick, Tongkeun Lee, Paul A. Janmey, Ravi Radhakrishnan

The paper investigates how cells from different tissue types respond to changes in ECM mechanics and composition, finding significant heterogeneity and the role of HA in modulating cell mechanics.

npj Biological Physics and Mechanics. · Aug 6, 2025Peer-reviewedBiophysics

Loss of vimentin intermediate filaments decreases peri-nuclear stiffness and enhances cell motility through confined spaces

Alison E. Patteson, Katarzyna Pogoda, Fitzroy J. Byfield, Elisabeth E. Charrier, Peter A. Galie, Piotr Deptuła, Robert Bucki, Paul A. Janmey

bioRxiv · Jul 17, 2018 · PreprintBiophysics