Dysregulated functional and metabolic response in multiple sclerosis patient macrophages correlate with a more inflammatory state, reminiscent of trained immunity
Jennifer Fransson, Corinne Bachelin, Florence Deknuydt, Farid Ichou, Léna Guillot‐Noël, Maharajah Ponnaiah, Arnaud Gloaguen, Élisabeth Maillart, Bruno Stankoff, Arthur Tenenhaus, Fanny Mochel, Bertrand Fontaine, Céline Louapre, Violetta Zujovic
The paper examines MS patient macrophages and finds they exhibit a pro-inflammatory transcriptomic and metabolic profile, suggesting intrinsic immune cell memory and potential therapeutic targets.
bioRxiv · Jan 13, 2021 · PreprintNeuroscience