Author

Jennifer Fransson

Centre National de la Recherche ScientifiqueORCID 0000-0003-4762-901XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:human· 3 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Violetta ZujoviciD· 3 shared Céline LouapreiD· 2 shared Afsana SabriniD· 1 shared Ana Isabel Gómez-Conde· 1 shared Anne Baron‐Van EvercooreniD· 1 shared Arnaud GloagueniD· 1 shared Arthur TenenhausiD· 1 shared Beatriz García-DíaziD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersNeuroscience

Violetta ZujovicORCID

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3 papers

Recent·Most cited

GenomicsbioRxivPreprintJun 29, 2022

Cell type- and state- resolved immune transcriptomic profiling identifies glucocorticoid-responsive molecular defects in multiple sclerosis T cells

Tina Roostaei, Afsana Sabrin, Pia Kivisäkk…·Philip L. De Jager

The paper identifies glucocorticoid-responsive molecular defects in MS T cells through cell-type-specific transcriptomic profiling and validates potential therapeutic targets.

3 citations

humanbulk RNA-seq

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NeurosciencebioRxivPreprintJan 13, 2021

Dysregulated functional and metabolic response in multiple sclerosis patient macrophages correlate with a more inflammatory state, reminiscent of trained immunity

Jennifer Fransson, Corinne Bachelin, Florence Deknuydt…·Violetta Zujovic

The paper examines MS patient macrophages and finds they exhibit a pro-inflammatory transcriptomic and metabolic profile, suggesting intrinsic immune cell memory and potential therapeutic targets.

3 citations

humanbulk RNA-seq

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NeuroscienceMolecular NeurobiologyPeer-reviewedSep 24, 2020

Activation of macrophages by lysophosphatidic acid through the lysophosphatidic acid receptor 1 as a novel mechanism in multiple sclerosis pathogenesis.

Jennifer Fransson, Ana Isabel Gómez-Conde, Jesús Romero-Imbroda…·Beatriz García-Díaz

This study shows that LPA1 receptor dysregulation in macrophages contributes to MS pathogenesis by promoting inflammation, with implications for therapeutic targeting.

31 citations

mousehuman

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