Violetta Zujovic

Patient-derived lymphocytes drive smoldering lesion pathology in a chimeric multiple sclerosis mouse model

This study shows that MS patient-derived lymphocytes in a chimeric mouse model drive smoldering lesion pathology, impair functional recovery, and alter CNS cell populations and myelination.

Cell type- and state- resolved immune transcriptomic profiling identifies glucocorticoid-responsive molecular defects in multiple sclerosis T cells

The paper identifies glucocorticoid-responsive molecular defects in MS T cells through cell-type-specific transcriptomic profiling and validates potential therapeutic targets.

Dysregulated functional and metabolic response in multiple sclerosis patient macrophages correlate with a more inflammatory state, reminiscent of trained immunity

The paper examines MS patient macrophages and finds they exhibit a pro-inflammatory transcriptomic and metabolic profile, suggesting intrinsic immune cell memory and potential therapeutic targets.

Activation of macrophages by lysophosphatidic acid through the lysophosphatidic acid receptor 1 as a novel mechanism in multiple sclerosis pathogenesis.

This study shows that LPA1 receptor dysregulation in macrophages contributes to MS pathogenesis by promoting inflammation, with implications for therapeutic targeting.

Blood vessels guide Schwann cell migration in the adult demyelinated CNS through Eph/ephrin signaling

This study shows that Schwann cells migrate along blood vessels in the demyelinated CNS via Eph/ephrin signaling, avoiding myelin and interacting with ECM components.