Florence Levillayer

Integration of past caspase activity biases cell elimination in vivo

The paper shows that past sublethal caspase activity influences cell elimination decisions in Drosophila, revealing a new layer of apoptosis regulation.

Developmental delay ensures global tissue size robustness upon local induction of apoptosis

The study shows that tissue size remains robust during mild apoptosis induction through a global growth delay rather than local proliferation, using Drosophila wing discs.

Patterned apoptosis has an instructive role for local growth and tissue shape in a fast-growing epithelium

This study shows that patterned apoptosis influences local growth and tissue shape in the Drosophila wing imaginal disc, challenging the assumption that cell death has minimal impact on organ size and morphology.

Robustness of epithelial sealing is an emerging property of local ERK feedbacks driven by cell elimination

The paper shows that local ERK feedbacks prevent concomitant cell elimination in epithelia, maintaining sealing during high cell death rates.

Competition for space induces cell elimination through compaction-driven ERK downregulation

The paper shows that tissue compaction induces cell elimination via ERK downregulation and Hid upregulation, contributing to clone expansion and tumor progression in Drosophila.