Romain Levayer

EpiCure is a tool for curating epithelial segmentation errors in 2D movies, improving accuracy and efficiency in single-cell dynamics analysis.

This study identifies two modes of cell compaction during mechanical cell competition: growth-driven and interfacial tension-driven, using Drosophila pupal notum.

The paper shows that past sublethal caspase activity influences cell elimination decisions in Drosophila, revealing a new layer of apoptosis regulation.

The study shows that tissue size remains robust during mild apoptosis induction through a global growth delay rather than local proliferation, using Drosophila wing discs.

This study shows that patterned apoptosis influences local growth and tissue shape in the Drosophila wing imaginal disc, challenging the assumption that cell death has minimal impact on organ size and morphology.

DeXtrusion automatically detects cell extrusion and death in epithelial tissues using machine learning, improving efficiency over manual methods.

This paper describes in-vitro protocols to differentiate mouse and human pluripotent cells into gonadal progenitors, revealing their functional equivalence to in-vivo cells and modeling DSDs.

The paper introduces LocalZProjector and DeProj, tools for accurate 2D projection and morphometric analysis of 3D microscopy images, showing they handle complex data and correct projection distortions.

The paper shows that local ERK feedbacks prevent concomitant cell elimination in epithelia, maintaining sealing during high cell death rates.

The paper shows that tissue compaction induces cell elimination via ERK downregulation and Hid upregulation, contributing to clone expansion and tumor progression in Drosophila.

The paper shows that Myc-induced cell mixing through intercalation drives competitive tissue invasion and destruction by altering cell interface tension and promoting loser cell elimination.