Léo Valon

EpiCure (Epithelial Curation): a versatile and handy tool for curation of epithelial segmentation

EpiCure is a tool for curating epithelial segmentation errors in 2D movies, improving accuracy and efficiency in single-cell dynamics analysis.

Adhesion-Controlled Mechanics of the Glial Niche Regulate Neural Stem Cell Proliferative Potential

This study shows that glial cell adhesion molecules regulate neural stem cell proliferation by modulating mechanical forces and nuclear integrity in Drosophila.

Control of cellular cortical tension and shape by RhoGTPase signalling

This study quantifies how RhoGTPase signalling controls cortical tension and cell shape using optogenetics and develops a predictive model linking signal gradients to mechanical changes.

Interfacial tension and growth both contribute to mechanical cell competition

This study identifies two modes of cell compaction during mechanical cell competition: growth-driven and interfacial tension-driven, using Drosophila pupal notum.

Integration of past caspase activity biases cell elimination in vivo

The paper shows that past sublethal caspase activity influences cell elimination decisions in Drosophila, revealing a new layer of apoptosis regulation.

DeXtrusion: Automatic recognition of epithelial cell extrusion through machine learning in vivo

DeXtrusion automatically detects cell extrusion and death in epithelial tissues using machine learning, improving efficiency over manual methods.

In-vitro cellular reprogramming to model gonad development and its disorders

This paper describes in-vitro protocols to differentiate mouse and human pluripotent cells into gonadal progenitors, revealing their functional equivalence to in-vivo cells and modeling DSDs.

LocalZProjector and DeProj: A toolbox for local 2D projection and accurate morphometrics of large 3D microscopy images.

The paper introduces LocalZProjector and DeProj, tools for accurate 2D projection and morphometric analysis of 3D microscopy images, showing they handle complex data and correct projection distortions.

Robustness of epithelial sealing is an emerging property of local ERK feedbacks driven by cell elimination

The paper shows that local ERK feedbacks prevent concomitant cell elimination in epithelia, maintaining sealing during high cell death rates.

Competition for space induces cell elimination through compaction-driven ERK downregulation

The paper shows that tissue compaction induces cell elimination via ERK downregulation and Hid upregulation, contributing to clone expansion and tumor progression in Drosophila.