A genome-wide in vivo CRISPR screen identifies neuroprotective strategies in the mouse and human retina
Ning Shen, Michael J. Fitzpatrick, Ellen G. Harding, Sohini Rebba, Florentina Soto, Philip A. Ruzycki, Daniel Kerschensteiner
The paper identifies neuroprotective genes in RP using CRISPR screens in mice and human retinal models, showing that UFD1 and UXT overexpression preserves photoreceptors and function.
Neuron · Apr 9, 2026Peer-reviewedNeuroscience