Philip A. Ruzycki

This study improves killifish retinal transcriptome annotation using long-read sequencing, identifying thousands of previously unannotated transcripts and enhancing gene naming accuracy.

The paper identifies neuroprotective genes in RP using CRISPR screens in mice and human retinal models, showing that UFD1 and UXT overexpression preserves photoreceptors and function.

This study identifies the lncRNA Peanut as promoting rod photoreceptor differentiation and neurogenesis by inhibiting Notch signaling and regulating Tox2 expression in retinal progenitor cells.

The paper shows that DNA demethylation, mediated by TET enzymes, is essential for rod-photoreceptor fate determination during retinal development.

This study uses bulk and single-cell RNA-seq to analyze age-related transcriptome changes in the African turquoise killifish retina, identifying oxidative stress, gliosis, and inflammageing, and highlighting dysregulation of retinal disease genes.

The paper investigates the role of Rho gene enhancers and promoter in mice, finding that enhancers are largely dispensable for Rho expression and rod cell function, while the promoter is essential.

This study investigates the roles of MLL1 and MLL2 in retinal development and cone cell maintenance using conditional knockout mice, revealing their redundant functions in neuronal maintenance and functional network establishment.

This study shows that Atoh7 is essential for RGC survival but not for their specification, as RGCs can develop without Atoh7 when apoptosis is inhibited.