Author

Michael J. Fitzpatrick

Washington University in St. LouisORCID 0000-0001-7663-2635Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Daniel KerschensteineriD· 2 shared Chi SuniD· 1 shared Ellen G. Harding· 1 shared Florentina Soto· 1 shared Ning SheniD· 1 shared Philip A. RuzyckiiD· 1 shared Shiming CheniD· 1 shared Sohini Rebba· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 18 mutual co-author links

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2 shared papersNeuroscience

Daniel KerschensteinerORCID

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2 papers

Recent·Most cited

NeuroscienceNeuronPeer-reviewedApr 9, 2026

A genome-wide in vivo CRISPR screen identifies neuroprotective strategies in the mouse and human retina

Ning Shen, Michael J. Fitzpatrick, Ellen G. Harding…·Daniel Kerschensteiner

The paper identifies neuroprotective genes in RP using CRISPR screens in mice and human retinal models, showing that UFD1 and UXT overexpression preserves photoreceptors and function.

1 citation

mousehuman

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NeurosciencebioRxivPreprintFeb 24, 2026

Preclinical CRX augmentation therapies for CRX-associated autosomal dominant cone-rod dystrophies

Chi Sun, Michael J. Fitzpatrick, Daniel Kerschensteiner, Shiming Chen

This study evaluates two CRX augmentation strategies in mouse models of CRX-associated CoRDs, showing improved cone and rod survival and function.

DOI 10.64898/2026.02.23.707517

mouseexperimental assay

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