Stable lentiviral-mediated expression of Cytochrome P450 2D6 in HepaRG cells: New means for in vitro assessment of xenobiotic biotransformation and cytotoxicity
Hugo Coppens-Exandier, Franz Mackanga, Thomas Darde, Corentin Bonhomme, Catherine Ribault, Thomas Gicquel, Romain Pelletier, Flyuza Roshchina, Estelle Schaefer, Christophe Chesné, Agnès Jamin, Anne Corlu, Pascal Loyer
This paper develops a method to enhance CYP2D6 expression in HepaRG cells using lentiviral transduction, demonstrating improved drug metabolism and toxicity assessment capabilities.
bioRxiv · Jan 25, 2025 · PreprintCell Biology