Cell BiologybioRxivPreprint
Stable lentiviral-mediated expression of Cytochrome P450 2D6 in HepaRG cells: New means for in vitro assessment of xenobiotic biotransformation and cytotoxicity
Hugo Coppens-Exandier, Franz Mackanga, Thomas Darde…·Pascal Loyer
This paper develops a method to enhance CYP2D6 expression in HepaRG cells using lentiviral transduction, demonstrating improved drug metabolism and toxicity assessment capabilities.
DOI 10.1101/2025.01.25.634872