Pascal Loyer

Voluntary wheel running selectively preserves skeletal muscle during pancreatic cancer cachexia despite persistent systemic alterations

This study compares voluntary wheel running and treadmill running in a pancreatic cancer model, finding that VWR preserves skeletal muscle while TR does not, despite similar systemic effects.

Isolation of rat and human hepatic cholangiocytes using a peptide derived from a conserved domain of enterobacteria BamA/TamA-like proteins

The paper identifies a peptide that binds to cholangiocytes and uses it to isolate human and rat liver epithelial cells, revealing functional differences between small and large cholangiocytes.

The dithiocarbamate pesticides maneb and mancozeb disturb the metabolism of lipids and xenobiotics in an in vitro model of metabolic dysfunction-associated steatotic liver disease

This study shows that maneb and mancozeb disrupt lipid and xenobiotic metabolism in HepaRG cells, especially when exposed to fatty acids.

Stable lentiviral-mediated expression of Cytochrome P450 2D6 in HepaRG cells: New means for in vitro assessment of xenobiotic biotransformation and cytotoxicity

This paper develops a method to enhance CYP2D6 expression in HepaRG cells using lentiviral transduction, demonstrating improved drug metabolism and toxicity assessment capabilities.

Insight Into the Molecular Parameters of PEI Promoting an Efficient Gene Delivery into Cells

This study investigates how molecular weight and structure of PEI affect polyplex stability, cell internalization, and transfection efficiency in HEK293T cells.

Efficient internalization of poly(benzyl malate) and poly(ethylene glycol)-b-poly(benzyl malate) copolymer based nanoparticles by human hepatic HepaRG cells and macrophages : Impact of nanoparticle functionalization by GBVA10-9 peptide on cell uptake.

This study compares nanoparticle uptake by HepaRG cells and macrophages, showing PMLABe-based NPs are efficiently internalized while PEGylated variants show reduced uptake, and GBVA10-9 peptide does not significantly affect uptake.