Author

Hugo Coppens-Exandier

Inserm

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1

Frequent Co-Authors

Anne CorluiD· 3 shared Pascal LoyeriD· 3 shared Catherine Ribault· 2 shared Agnès JaminiD· 1 shared Bernard FromentyiD· 1 shared Camille C. SavaryiD· 1 shared Christophe ChesnéiD· 1 shared Corentin Bonhomme· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCell Biology

Anne CorluORCID

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Author profile →

3 papers

Recent·Most cited

Isolation of rat and human hepatic cholangiocytes using a peptide derived from a conserved domain of enterobacteria BamA/TamA-like proteins

Perla METLEJ, Catherine Ribault, Sandrine Le Gall‐David, Hanadi Nahas, Patricia Leroyer, Kevin Maunand, Nina Soler, Hugo Coppens-Exandier, Manuel Vlach, Dani Osman, Latifa Bousarghin, Anne Corlu, Pascal Loyer

The paper identifies a peptide that binds to cholangiocytes and uses it to isolate human and rat liver epithelial cells, revealing functional differences between small and large cholangiocytes.

bioRxiv · Nov 3, 2025 · PreprintCell Biology

The dithiocarbamate pesticides maneb and mancozeb disturb the metabolism of lipids and xenobiotics in an in vitro model of metabolic dysfunction-associated steatotic liver disease

Kilian Petitjean, Giovanna Dicara, Sébastien Bristeau, Hugo Coppens-Exandier, Laurence Amalric, Nicole Baran, Camille C. Savary, Anne Corlu, Pascal Loyer, Bernard Fromenty

This study shows that maneb and mancozeb disrupt lipid and xenobiotic metabolism in HepaRG cells, especially when exposed to fatty acids.

Environmental Toxicology and Pharmacology · Jul 22, 2025Peer-reviewedPharmacology & Toxicology

Stable lentiviral-mediated expression of Cytochrome P450 2D6 in HepaRG cells: New means for in vitro assessment of xenobiotic biotransformation and cytotoxicity

Hugo Coppens-Exandier, Franz Mackanga, Thomas Darde, Corentin Bonhomme, Catherine Ribault, Thomas Gicquel, Romain Pelletier, Flyuza Roshchina, Estelle Schaefer, Christophe Chesné, Agnès Jamin, Anne Corlu, Pascal Loyer

This paper develops a method to enhance CYP2D6 expression in HepaRG cells using lentiviral transduction, demonstrating improved drug metabolism and toxicity assessment capabilities.

bioRxiv · Jan 25, 2025 · PreprintCell Biology