Anne Corlu

Voluntary wheel running selectively preserves skeletal muscle during pancreatic cancer cachexia despite persistent systemic alterations

This study compares voluntary wheel running and treadmill running in a pancreatic cancer model, finding that VWR preserves skeletal muscle while TR does not, despite similar systemic effects.

PPARgamma, a key modulator of metabolic reprogramming, stemness and chemoresistance associated with retrodifferentiation in human hepatocellular carcinomas

This study identifies PPARgamma as a key regulator of metabolic reprogramming and stemness in hepatic CSCs, linking it to chemoresistance in HCC.

Isolation of rat and human hepatic cholangiocytes using a peptide derived from a conserved domain of enterobacteria BamA/TamA-like proteins

The paper identifies a peptide that binds to cholangiocytes and uses it to isolate human and rat liver epithelial cells, revealing functional differences between small and large cholangiocytes.

The dithiocarbamate pesticides maneb and mancozeb disturb the metabolism of lipids and xenobiotics in an in vitro model of metabolic dysfunction-associated steatotic liver disease

This study shows that maneb and mancozeb disrupt lipid and xenobiotic metabolism in HepaRG cells, especially when exposed to fatty acids.

Stable lentiviral-mediated expression of Cytochrome P450 2D6 in HepaRG cells: New means for in vitro assessment of xenobiotic biotransformation and cytotoxicity

This paper develops a method to enhance CYP2D6 expression in HepaRG cells using lentiviral transduction, demonstrating improved drug metabolism and toxicity assessment capabilities.

Epigenetic heterogeneity after de novo assembly of native full-length Hepatitis B Virus genomes

The paper develops a method to detect 5mCpG in HBV genomes without bisulfite conversion, enabling de novo assembly and identification of epigenetic clusters in infected patients.