Bypassing cisplatin resistance in Nrf2 hyperactivated head and neck cancer through effective PI3Kinase targeting
Pedram Yadollahi, Kelli A. McCord, Li Yang, Hussam Dayoub, Kalil Saab, Fonma Essien, Sean Hyslop, Emerald Kan, Kazi Mokim Ahmed, Parker R. Kirby, Vasanta Putluri, Chandrashekar R. Ambati, Karthik Reddy Kami Reddy, Patricia D. Castro, Heath Devin Skinner, , Vlad Constantin Sandulache
This paper identifies PI3K pathway activation in Nrf2-driven cisplatin-resistant HNSCC and shows that gedatolisib inhibits tumor growth and re-sensitizes cells to cisplatin.
British Journal of Cancer · Oct 6, 2025Peer-reviewedCancer Biology