Single-cell, Spatially-Resolved TCR Profiling Links T Cell Phenotype and Clonality in Human Tumors
Kelli A. McCord, Emerald Kan, Sean Hyslop, Amanda Y. Xia, Colby J. Hofferek, James S. Lewis, Andreas Wieland, David J. Hernandez, Vlad Constantin Sandulache, William Henry Hudson
The paper develops a multimodal profiling framework to analyze T cell phenotype and clonality in HNSCC tumors, revealing spatial and antigen-specific differences in T cell function.
Science Immunology · Apr 10, 2026Peer-reviewedImmunology