NOTCH1 Acts as a Tumor Suppressor That Induces Early Differentiation in Head and Neck Cancer
Chenfei Huang, Shhyam Moorthy, Qiuli Li, Kazi Mokim Ahmed, Kalil Saab, Defeng Deng, Jiping Wang, Xiayu Rao, Jiexin Zhang, Yuanxin Xi, Jing Wang, Zhiyi Liu, Noriaki Tanaka, David A. Wheeler, Eve Shinbrot, , Mitchell J. Frederick
This study clarifies that NOTCH1 acts as a tumor suppressor in head and neck cancer, reducing cancer stem cells and improving prognosis, despite conflicting prior reports.
JCI Insight · Apr 16, 2026Peer-reviewedCancer Biology