Vlad Constantin Sandulache

Targeted suppression of SPP1 inhibits tumor invasion and metastasis in NRF2 hyperactivated cisplatin resistant HNSCC

This study shows that suppressing SPP1 improves cisplatin sensitivity and inhibits tumor invasion and metastasis in NRF2-hyperactivated cisplatin-resistant HNSCC.

NOTCH1 Acts as a Tumor Suppressor That Induces Early Differentiation in Head and Neck Cancer

This study clarifies that NOTCH1 acts as a tumor suppressor in head and neck cancer, reducing cancer stem cells and improving prognosis, despite conflicting prior reports.

Single-cell, Spatially-Resolved TCR Profiling Links T Cell Phenotype and Clonality in Human Tumors

The paper develops a multimodal profiling framework to analyze T cell phenotype and clonality in HNSCC tumors, revealing spatial and antigen-specific differences in T cell function.

Bypassing cisplatin resistance in Nrf2 hyperactivated head and neck cancer through effective PI3Kinase targeting

This paper identifies PI3K pathway activation in Nrf2-driven cisplatin-resistant HNSCC and shows that gedatolisib inhibits tumor growth and re-sensitizes cells to cisplatin.

Reliable RNA-seq analysis from FFPE specimens as a means to accelerate cancer-related health disparities research

This study develops reliable RNA-seq methods for FFPE specimens to analyze transcriptional profiles in OPSCC, enabling health disparities research.

Tobacco smoke exposure is a driver of altered oxidative stress response and immunity in head and neck cancer

This study shows cigarette smoke exposure drives aggressive head and neck cancer by altering oxidative stress response and immunity through Nrf2 activation and metabolic reprogramming.