Decoding the BRCA2 reversion principles underlying PARP inhibitor resistance
Anna Horacek, Frances Li Kueper, Robert Lu, Isabella Paige Lamont, Stella Tran, Hanqin Li, Dirk F. Hockemeyer
The paper identifies principles governing BRCA2 reversion mutations that confer resistance to PARP inhibitors using CRISPR editing and an isogenic cell system.
bioRxiv · May 10, 2026 · PreprintCancer Biology