Author

Yanbo Wang

Stanford MedicineORCID 0000-0002-0787-7361Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Howard Y. ChangiD· 4 shared Paul S. MischeliD· 4 shared Rui LiiD· 4 shared Ivy Tsz-Lo WongiD· 3 shared Jens LuebeckiD· 3 shared Katerina KraftiD· 3 shared Natasha E. WeiseriD· 3 shared Shu ZhangiD· 3 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

Howard Y. ChangORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Inverted logic of ecDNA localization converts nuclear periphery into oncogenic transcription hubs in cancer

Yanbo Wang, Xiaowei Yan, Natasha E. Weiser, Ivy Tsz-Lo Wong, Shu Zhang, Yung‐Hsin Huang, Rui Li, Katerina Kraft, Aditi Gnanasekar, Jun Tang, Cy Chittenden, Lotte Brückner, Imran Noorani, Charles Swanton, Anton George Henssen, , Paul S. Mischel

The paper shows ecDNA localizes to the nuclear periphery in cancer, resisting silencing and enhancing transcriptional output through interactions with the nuclear lamina.

bioRxiv · Sep 17, 2026 · PreprintCancer Biology

Enhancer activation from transposable elements in extrachromosomal DNA

Katerina Kraft, Sedona E. Murphy, Matthew G. Jones, Quanming Shi, Aarohi Bhargava-Shah, Christy Luong, King L. Hung, Britney Jiayu He, Rui Li, Seung Kuk Park, Michael T. Montgomery, Natasha E. Weiser, Yanbo Wang, Jens Luebeck, Vineet Bafna, , Howard Y. Chang

The paper identifies enhancer-like elements on ecDNA in colorectal cancer that are derived from transposable elements and are functionally active in cancer cell fitness.

Nature Cell Biology · Oct 21, 2025Peer-reviewedGenetics

EcDNA-borne PVT1 fusion stabilizes oncogenic mRNAs

Hyerim Yi, Shu Zhang, Jason T. Swinderman, Yanbo Wang, Vishnupriya Kanakaveti, King L. Hung, Ivy Tsz-Lo Wong, Suhas Srinivasan, Ellis J. Curtis, Aarohi Bhargava-Shah, Rui Li, Matthew G. Jones, Jens Luebeck, Yanding Zhao, Julia A. Belk, , Howard Y. Chang

The paper shows that ecDNA-borne PVT1 fusions stabilize oncogenic mRNAs by interacting with SRSF1, enhancing RNA stability and supporting MYC dependency in cancer.

bioRxiv · Apr 1, 2025 · PreprintCancer Biology

Rampant transcription replication conflict creates therapeutic vulnerability in extrachromosomal DNA containing cancers

Jun Tang, Natasha E. Weiser, Guiping Wang, Sudhir Chowdhry, Ellis J. Curtis, Yanding Zhao, Ivy Tsz-Lo Wong, Georgi K. Marinov, Rui Li, Philip Hanoian, Edison Tse, Salvador Garcia Mojica, Ryan J. Hansen, Joshua Plum, Auzon Steffy, , Howard Y. Chang

This paper identifies transcription-replication conflict as a vulnerability in ecDNA-containing cancers and demonstrates that CHK1 inhibition selectively kills these tumors.

Nature · Nov 6, 2024Peer-reviewedCancer Biology