Author

Frances Shanahan

Genentech

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Systems Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:simulation· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrew Goetz· 1 shared Bartosz CzechiD· 1 shared Darlene Dela Cruz· 1 shared Eva LiniD· 1 shared Logan BrooksiD· 1 shared Luca GerosaiD· 1 shared Purushottam D. DixitiD· 1 shared Rana M Mroue· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperSystems Biology

Andrew Goetz

Mutual co-authors in cluster

Author profile →

1 paper

Recent·Most cited

Computational modeling of drug response identifies mutant-specific constraints for dosing panRAF and MEK inhibitors in melanoma

Andrew Goetz, Frances Shanahan, Logan Brooks, Eva Lin, Rana M Mroue, Darlene Dela Cruz, Thomas Hunsaker, Bartosz Czech, Purushottam D. Dixit, Udi Segal, Scott E. Martin, Scott A. Foster, Luca Gerosa

This study uses computational modeling and preclinical data to identify optimal dosing strategies for panRAF and MEK inhibitors in melanoma, revealing distinct dose requirements based on NRAS vs BRAF mutations.

Cancers · Aug 22, 2024Peer-reviewedSystems Biology