Scott E. Martin

Single-cell and spatial maps of human coronary arteries identify FAP as a marker of SMC-derived modulated cells; an anti-FAP BiTE reduced plaque burden in mouse models.

The paper uses a CRISPR/Cas9 screen to identify genes modulating ASO activity, revealing AP1M1 and TBC1D23 as key regulators of endosome-Golgi transport affecting ASO efficacy.

The paper identifies bZIP transcription factors as key regulators of IL-2-induced Treg activation, linking chromatin accessibility changes to Th1/Th2 molecular phenotypes and metabolic pathways.

The paper identifies regulators of inflammatory macrophage states and shows that TNF mRNA m6A modification controls its stability and contributes to disease.

This study uses computational modeling and preclinical data to identify optimal dosing strategies for panRAF and MEK inhibitors in melanoma, revealing distinct dose requirements based on NRAS vs BRAF mutations.

PharmacoDB 2.0 enhances pharmacogenomics analysis by integrating new datasets, implementing FAIR pipelines, and improving drug response analysis tools.

The paper introduces a cloud-based platform called ORCESTRA for reproducible processing and sharing of multimodal biomedical data in a FAIR manner.

The paper analyzes how multi-target sgRNAs in CRISPR screens introduce biases in essentiality scores and functional networks.