Luca Gerosa

This study uses computational modeling and preclinical data to identify optimal dosing strategies for panRAF and MEK inhibitors in melanoma, revealing distinct dose requirements based on NRAS vs BRAF mutations.

The paper models MAPK signaling in BRAFV600E melanoma cells to show how allostery and rewiring lead to drug resistance.

The paper introduces a method called Dye Drop for high-throughput single-cell assays in 384-well plates, enabling detailed dose-response analysis of small molecules in breast cancer cell lines.

The paper investigates how varying ERK activity levels influence proliferation in cells undergoing oncogene-induced senescence, finding intermediate ERK activity promotes maximal proliferation.