A chicken interferon stimulated gene screen reveals limited genes restricting influenza replication
Alison J. Barkhymer, Jordan T. Becker, Frances Shepherd, Clayton K. Mickelson, Lauren M. Pross, Mark Salnikov, Ryan Andrew Langlois
This study identifies interferon-stimulated genes (ISGs) in chicken, quail, and duck cells and performs a CRISPR knockout screen to find genes restricting influenza replication, revealing species-specific differences in antiviral immunity.
bioRxiv · Jul 24, 2026 · PreprintMicrobiology