Clayton K. Mickelson

A mammalian fibroblast zoo reveals barriers to cross-species virus replication and differential regulation of antiviral immunity

The paper uses fibroblasts from 86 mammalian species to study virus-host susceptibility and innate immune responses across diverse mammals.

Genetic ancestry shapes context-dependent immune regulation across Indigenous South American populations

The paper generates a single-cell transcriptional atlas of Indigenous South American populations and shows genetic ancestry influences immune gene expression, particularly after stimulation.

A chicken interferon stimulated gene screen reveals limited genes restricting influenza replication

This study identifies interferon-stimulated genes (ISGs) in chicken, quail, and duck cells and performs a CRISPR knockout screen to find genes restricting influenza replication, revealing species-specific differences in antiviral immunity.

Mammalian ZAP and KHNYN can independently restrict CpG-enriched avian viruses

The paper shows mammalian ZAP and KHNYN can restrict CpG-enriched avian viruses, with human ZAP or KHNYN independently limiting CpG-enriched IAV in chicken and human cells.

Intrinsic OASL expression licenses interferon induction during influenza A virus infection

The paper identifies intrinsic OASL expression as a determinant of IFN induction potential in influenza A virus-infected cells using scRNA-seq analysis.