Alison J. Barkhymer

A chicken interferon stimulated gene screen reveals limited genes restricting influenza replication

This study identifies interferon-stimulated genes (ISGs) in chicken, quail, and duck cells and performs a CRISPR knockout screen to find genes restricting influenza replication, revealing species-specific differences in antiviral immunity.

Mammalian ZAP and KHNYN can independently restrict CpG-enriched avian viruses

The paper shows mammalian ZAP and KHNYN can restrict CpG-enriched avian viruses, with human ZAP or KHNYN independently limiting CpG-enriched IAV in chicken and human cells.