Oligosaccharyltransferase (OST) complex inhibition effectively treats rodent and human prions
Kathryn S. Beauchemin, Judit Kun, Bradley R. Groveman, Katie Williams, Francesca Salerno, Lisa M. Francomacaro, Patrick Robison, Cathryn L. Haigh, Surachai Supattapone
This paper identifies OST complex inhibition as a novel therapeutic approach that reduces prion protein surface expression and prevents prion amplification in both rodent and human prion models.
PLoS Pathogens · Jan 12, 2026Peer-reviewedCell Biology