Cell BiologyPLoS PathogensPeer-reviewed
Oligosaccharyltransferase (OST) complex inhibition effectively treats rodent and human prions
Kathryn S. Beauchemin, Judit Kun, Bradley R. Groveman…·Surachai Supattapone
This paper identifies OST complex inhibition as a novel therapeutic approach that reduces prion protein surface expression and prevents prion amplification in both rodent and human prion models.