Kathryn S. Beauchemin

The paper identifies two classes of nanobodies that inhibit Cif, an epoxide hydrolase from Pseudomonas aeruginosa, through distinct structural strategies targeting a shared epitope.

This study identifies GSK-3β as a regulator of PrPC levels through post-translational mechanisms and shows its impact on PrPSc levels in prion-infected cells.

This study identifies mitochondrial energy production as a key host factor mediating cell death from CSG orthobunyaviruses and shows that reducing energy production can protect cells from viral infection.

The paper identifies core regulators of cell surface PrPC expression through CRISPR screens in neuronal cells, revealing shared and unique regulators in different cell states.

This paper identifies OST complex inhibition as a novel therapeutic approach that reduces prion protein surface expression and prevents prion amplification in both rodent and human prion models.