Cathryn L. Haigh

This study shows that proteasome mutations in CANDLE syndrome disrupt neuronal development by increasing polyamine levels through ODC dysregulation, and inhibiting ODC can reverse these effects.

This paper identifies OST complex inhibition as a novel therapeutic approach that reduces prion protein surface expression and prevents prion amplification in both rodent and human prion models.

This study identifies ADAM10-mediated shedding of human PrP at Y226 and shows sPrP associates with misfolded protein aggregates in neurodegenerative diseases.