Simple Sequence Repeats Mediate Phase Variation of the Mucoid Phenotype in Hypervirulent Klebsiella pneumoniae
Oliwia Stawarska, Aarabhi Ravikrishnan Nair, Ania W. Y. Man, Luke R. Green, Ozcan Gazioglu, Francesco Flandi, Margaret M. C. Lam, Kathryn E. Holt, Hasan Yeşilkaya, Marco Rinaldo Oggioni, José Antonio Bengoechea, Charlotte Odendall, Alex J. McCarthy, Joseph J. Wanford
This study identifies simple sequence repeats in rmpA and rmpD/rmpC genes that mediate phase variation of the mucoid phenotype in hypervirulent Klebsiella pneumoniae, enabling adaptation to different infection niches.
bioRxiv · Sep 12, 2025 · PreprintMicrobiology