José Antonio Bengoechea

SdiA as a Repressor of Phagocytosis and Intracellular Survival in Klebsiella pneumoniae: Insights from Macrophage and Amoeba Models

This paper shows that SdiA in Klebsiella pneumoniae represses phagocytosis and intracellular survival, with mutant strains being more susceptible to phagocytosis but showing increased intracellular fitness and host cell death.

Simple Sequence Repeats Mediate Phase Variation of the Mucoid Phenotype in Hypervirulent Klebsiella pneumoniae

This study identifies simple sequence repeats in rmpA and rmpD/rmpC genes that mediate phase variation of the mucoid phenotype in hypervirulent Klebsiella pneumoniae, enabling adaptation to different infection niches.

Klebsiella pneumoniae remodels its Kdo2-lipid A in a TLR4-dependent manner to adapt to the macrophage intracellular environment

This study shows Klebsiella pneumoniae modifies its lipid A in response to macrophage environment, enhancing survival and immune evasion through TLR4-dependent mechanisms.

Interrogating the genus Yersinia to define the rules of lipopolysaccharide lipid A structure associated with pathogenicity.

The paper investigates how lipid A modifications in Yersinia species influence pathogenicity by altering TLR4 recognition and inflammation.

Klebsiella pneumoniae disrupts vasodilation by targeting eNOS post translational modifications via the type VI secretion system and the capsule polysaccharide

This study shows Klebsiella pneumoniae inhibits vasodilation by targeting eNOS post-translational modifications through its T6SS and capsule polysaccharide.

A gas phase fractionation acquisition scheme integrating ion mobility for rapid diaPASEF library generation

The paper introduces an ion mobility-integrated gas phase fractionation (IM-GPF) method for rapid diaPASEF library generation, outperforming direct deconvolution and approaching offline fractionation performance.