Author

Franz Arnold Ake

Institut d'Investigació Biomédica de Bellvitge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Mireya PlassiD· 3 shared Ana Gutiérrez-FrancoiD· 2 shared Loris MularoniiD· 2 shared Akshay Jaya GaneshiD· 1 shared Ángel RayaiD· 1 shared Antonella ConsiglioiD· 1 shared Christin WeisslederiD· 1 shared Giulia Simmini· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersCell Biology

Mireya PlassORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Astrocytic Ceruloplasmin Deficiency Triggers Iron Toxicity and Neurodegeneration in a LRRK2 Parkinson's Tri-Culture Model

Veronica Testa, Jara Montero-Muñoz, Valentina Baruffi, Marieke Alzeer, Loris Mularoni, Irene Fernández‐Carasa, Giulia Simmini, Núria Comellas-Comaposada, Franz Arnold Ake, Yvonne Richaud, Christin Weissleder, Josep Amengual, Isabel Fabregat, Michela Deleidi, Mireya Plass, , Antonella Consiglio

This study identifies ceruloplasmin deficiency in mutant astrocytes as a driver of iron toxicity and neurodegeneration in a Parkinson's tri-culture model.

bioRxiv · Aug 1, 2025 · PreprintCell Biology

Quantification of transcript isoforms at the single-cell level using SCALPEL

Franz Arnold Ake, Marcel Schilling, Sandra M. Fernández Moya, Akshay Jaya Ganesh, Ana Gutiérrez-Franco, Lei Li, Mireya Plass

SCALPEL quantifies single-cell transcript isoforms with higher sensitivity than existing tools, revealing novel cell populations and isoform regulation in mouse spermatogenesis and iPSC differentiation.

Nature Communications · Jul 11, 2025Peer-reviewedBioinformatics

Methanol fixation is the method of choice for droplet-based single-cell transcriptomics of neural cells

Ana Gutiérrez-Franco, Franz Arnold Ake, Mohamed N. Hassan, Natalie Chaves Cayuela, Loris Mularoni, Mireya Plass

This study compares preservation methods for scRNA-seq of neural cells, finding that methanol fixation best preserves cellular composition and expression profiles.

Communications Biology · May 15, 2023Peer-reviewedGenomics