Mireya Plass

Staufen2 modulates the temporal dynamics of human neurogenesis in vitro

This study shows that STAU2 regulates human neurogenesis by affecting transcription factors, miRNA control, and progenitor maintenance, leading to changes in neural differentiation and organoid development.

Astrocytic Ceruloplasmin Deficiency Triggers Iron Toxicity and Neurodegeneration in a LRRK2 Parkinson's Tri-Culture Model

This study identifies ceruloplasmin deficiency in mutant astrocytes as a driver of iron toxicity and neurodegeneration in a Parkinson's tri-culture model.

Quantification of transcript isoforms at the single-cell level using SCALPEL

SCALPEL quantifies single-cell transcript isoforms with higher sensitivity than existing tools, revealing novel cell populations and isoform regulation in mouse spermatogenesis and iPSC differentiation.

A distinct class of pan cancer susceptibility genes revealed by alternative polyadenylation transcriptome wide association study

This study identifies 413 APA-linked cancer susceptibility genes by integrating GWAS data with APA quantification, showing genetic variants associated with APA explain a large portion of cancer heritability.

Methanol fixation is the method of choice for droplet-based single-cell transcriptomics of neural cells

This study compares preservation methods for scRNA-seq of neural cells, finding that methanol fixation best preserves cellular composition and expression profiles.

Graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells

This paper introduces PAGA, a method that reconciles clustering with trajectory inference by creating a topology-preserving graph map of single-cell data, demonstrating its effectiveness across multiple datasets.