Author

Valentina Baruffi

Bellvitge University HospitalORCID 0000-0002-7722-7268Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cell-cell communication· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:imaging· 1

Frequent Co-Authors

Ángel RayaiD· 3 shared Antonella ConsiglioiD· 3 shared Irene Fernández‐CarasaiD· 3 shared Jara Montero-MuñoziD· 2 shared Lucas Blasco-AgelliD· 2 shared Manel JuaniD· 2 shared Meritxell Pons‐EspinaliD· 2 shared Veronica TestaiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersCell Biology

Ángel RayaORCID

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3 papers

Recent·Most cited

LRRK2-mutant microglia and neuromelanin synergize to drive dopaminergic neurodegeneration in an iPSC-based Parkinson's disease model

Lucas Blasco-Agell, Meritxell Pons‐Espinal, Veronica Testa, Gerard Roch, Jara Montero-Muñoz, Irene Fernández‐Carasa, Valentina Baruffi, Marta González-Sepúlveda, Yvonne Richaud‐Patín, Senda Jiménez‐Delgado, Thais Cuadros, Joana M. Cladera-Sastre, Joan Compte, Zoe Manglano-Artuñedo, Salvador Ventura, , Antonella Consiglio

LRRK2 G2019S iPSC-derived microglia exposed to neuromelanin, but not α-synuclein fibrils, reduce healthy dopaminergic neuron numbers in co-culture; ivermectin prevents this, and post-mortem midbrain supports it.

Communications Biology · Aug 12, 2025Peer-reviewedCell Biology✦ In-depth digest

Astrocytic Ceruloplasmin Deficiency Triggers Iron Toxicity and Neurodegeneration in a LRRK2 Parkinson's Tri-Culture Model

Veronica Testa, Jara Montero-Muñoz, Valentina Baruffi, Marieke Alzeer, Loris Mularoni, Irene Fernández‐Carasa, Giulia Simmini, Núria Comellas-Comaposada, Franz Arnold Ake, Yvonne Richaud, Christin Weissleder, Josep Amengual, Isabel Fabregat, Michela Deleidi, Mireya Plass, , Antonella Consiglio

This study identifies ceruloplasmin deficiency in mutant astrocytes as a driver of iron toxicity and neurodegeneration in a Parkinson's tri-culture model.

bioRxiv · Aug 1, 2025 · PreprintCell Biology

Immunosuppressive tocilizumab prevents astrocyte induced neurotoxicity in hiPSC-LRRK2 Parkinson's disease by targeting receptor interleukin-6

Meritxell Pons‐Espinal, Lucas Blasco-Agell, Irene Fernández‐Carasa, Pol Andrés‐Benito, Angelique di Domenico, Yvonne Richaud‐Patín, Valentina Baruffi, Laura Marruecos, Lluı́s Espinosa, Alícia Garrido, EDUARDO S. TOLOSA, Michael J. Edel, Manel Juan, José Luis Mosquera, Isidró Ferrer, , Antonella Consiglio

The paper shows that tocilizumab, an IL-6 receptor inhibitor, prevents astrocyte-induced neurotoxicity in Parkinson's disease by blocking IL-6 signaling in neurons.

JCI Insight · Feb 8, 2024Peer-reviewedNeuroscience