Astrocytic Ceruloplasmin Deficiency Triggers Iron Toxicity and Neurodegeneration in a LRRK2 Parkinson's Tri-Culture Model
Veronica Testa, Jara Montero-Muñoz, Valentina Baruffi, Marieke Alzeer, Loris Mularoni, Irene Fernández‐Carasa, Giulia Simmini, Núria Comellas-Comaposada, Franz Arnold Ake, Yvonne Richaud, Christin Weissleder, Josep Amengual, Isabel Fabregat, Michela Deleidi, Mireya Plass, , Antonella Consiglio
This study identifies ceruloplasmin deficiency in mutant astrocytes as a driver of iron toxicity and neurodegeneration in a Parkinson's tri-culture model.
bioRxiv · Aug 1, 2025 · PreprintCell Biology