Stem cells actively suppress regenerative plasticity in human colon
Joris H. Hageman, Defne Yalçin, Julian R. Buissant des Amorie, Sascha R. Brunner, Thomas A. Kluiver, Aleksandra Balwierz, Franziska L. Langner, Maria C. Puschhof, Yannik Bollen, Thanasis Margaritis, Hugo J.G. Snippert
The paper investigates human colon stem cell function, showing they suppress regenerative plasticity by producing retinoic acid, which inhibits the regenerative response in colonocytes.
bioRxiv · Jul 13, 2025 · PreprintCell Biology