Hugo J.G. Snippert

Chromosome 7 gain establishes a just-right WNT signaling state during colorectal tumorigenesis

This study shows that chromosome 7 gain optimizes WNT signaling in colorectal cancer by counteracting excessive stemness from APC mutations.

Mature tuft cell phenotypes are sequentially expressed along the intestinal crypt-villus axis following cytokine-induced tuft cell hyperplasia

The paper identifies sequential transcriptomic states of tuft cells along the intestinal crypt-villus axis and shows cytokine-specific differentiation into distinct tuft cell phenotypes.

Stem cells actively suppress regenerative plasticity in human colon

The paper investigates human colon stem cell function, showing they suppress regenerative plasticity by producing retinoic acid, which inhibits the regenerative response in colonocytes.

Sensitivity to Vγ9Vδ2TCR T cells is imprinted after single mutations during early oncogenesis

This study shows that single mutations during early oncogenesis can upregulate BTN2A1, enabling Vγ9Vδ2 TCR binding, but full activation requires subsequent phosphorylation of BTN3A1.

APOBEC3A, not APOBEC3B, drives deaminase mutagenesis in human gastric epithelium

This study shows APOBEC3A, not APOBEC3B, causes significant mutagenesis in human gastric epithelium through whole-genome sequencing of organoids with inducible APOBEC3A or APOBEC3B.

Multi range ERK responses shape the proliferative trajectory of single cells following oncogene induced senescence

The paper investigates how varying ERK activity levels influence proliferation in cells undergoing oncogene-induced senescence, finding intermediate ERK activity promotes maximal proliferation.