Author

Sascha R. Brunner

University Medical Center UtrechtORCID 0009-0003-6579-1587Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Hugo J.G. SnippertiD· 2 shared Joris H. HagemaniD· 2 shared Julian R. Buissant des AmorieiD· 2 shared Aleksandra BalwierziD· 1 shared Ali MovasatiiD· 1 shared Arne van HoeckiD· 1 shared Defne Yalçin· 1 shared Dimitrios LaskarisiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

Hugo J.G. SnippertORCID

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3 papers

Recent·Most cited

Cell BiologyNature CommunicationsPeer-reviewedJul 22, 2025

Mature tuft cell phenotypes are sequentially expressed along the intestinal crypt-villus axis following cytokine-induced tuft cell hyperplasia

Julian R. Buissant des Amorie, Max A. Betjes, Jochem H. Bernink…·Hugo J.G. Snippert

The paper identifies sequential transcriptomic states of tuft cells along the intestinal crypt-villus axis and shows cytokine-specific differentiation into distinct tuft cell phenotypes.

18 citationstop 2%

mousehuman

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Cell BiologybioRxivPreprintJul 13, 2025

Stem cells actively suppress regenerative plasticity in human colon

Joris H. Hageman, Defne Yalçin, Julian R. Buissant des Amorie…·Hugo J.G. Snippert

The paper investigates human colon stem cell function, showing they suppress regenerative plasticity by producing retinoic acid, which inhibits the regenerative response in colonocytes.

3 citations

humanorganoid / primary culture

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GenomicsbioRxivPreprintJun 17, 2022

Pan-cancer whole genome comparison of primary and metastatic solid tumors

Francisco Martínez-Jiménez, Ali Movasati, Sascha R. Brunner…·Arne van Hoeck

This study compares whole-genome sequences of primary and metastatic tumors across 7,152 samples, revealing cancer-type-specific genomic changes and treatment-induced evolutionary bottlenecks.

15 citations

humanwhole-genome sequencing

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