Structure of human cytoplasmic Pol II complex explains global transcription repression by Gdown1
Jana Schmitzová, Yumeng Zhan, Srinivasan Rengachari, Frauke Grabbe, Olexandr Dybkov, Henning Urlaub, Michael Lidschreiber, Christian Dienemann, Patrick Cramer
The paper determines the cryo-EM structure of cytoplasmic Pol II and shows Gdown1 inhibits its transcriptional activity by blocking essential factor binding.
Nature Communications · Aug 5, 2026Peer-reviewedBiochemistry