Author

Srinivasan Rengachari

Max Planck SocietyORCID 0000-0003-4237-8258Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:protein structure prediction· 2 Assay:ChIP-seq· 1 Assay:cryo-EM· 1

Frequent Co-Authors

Christian DienemanniD· 3 shared Patrick CrameriD· 3 shared Henning UrlaubiD· 2 shared S. SchilbachiD· 2 shared Alessandro VanniniiD· 1 shared Frauke Grabbe· 1 shared Jana SchmitzováiD· 1 shared Jérôme GougeiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersMolecular Biology

Christian DienemannORCID

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3 papers

Recent·Most cited

Structure of human cytoplasmic Pol II complex explains global transcription repression by Gdown1

Jana Schmitzová, Yumeng Zhan, Srinivasan Rengachari, Frauke Grabbe, Olexandr Dybkov, Henning Urlaub, Michael Lidschreiber, Christian Dienemann, Patrick Cramer

The paper determines the cryo-EM structure of cytoplasmic Pol II and shows Gdown1 inhibits its transcriptional activity by blocking essential factor binding.

Nature Communications · Aug 5, 2026Peer-reviewedBiochemistry

Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II

Srinivasan Rengachari, S. Schilbach, Thangavelu Kaliyappan, Jérôme Gouge, Kristina Žumer, Juliane Schwarz, Henning Urlaub, Christian Dienemann, Alessandro Vannini, Patrick Cramer

This study determines the structural basis of RNA polymerase II initiation at snRNA promoters using SNAPc, revealing its role in DNA opening and transcription initiation independent of TFIIE and TFIIH.

Nature Structural & Molecular Biology · Nov 24, 2022Peer-reviewedMolecular Biology

Structure of human Mediator-RNA polymerase II transcription pre-initiation complex

Srinivasan Rengachari, S. Schilbach, Shintaro Aibara, Christian Dienemann, Patrick Cramer

The paper determines the structure of the human Mediator-RNA polymerase II transcription pre-initiation complex using cryo-EM, revealing interactions and conformational changes involved in transcription initiation.

Nature · Apr 26, 2021Peer-reviewedMolecular Biology