Author

Freesia L. Huang

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Assay:metabolomics· 1

Frequent Co-Authors

Gerald R. CrabtreeiD· 2 shared Hideo HagiharaiD· 2 shared Isabella A. Graef· 2 shared Keiichi I. NakayamaiD· 2 shared Tsuyoshi TakagiiD· 2 shared Yuta Katayama· 2 shared Akiko Hayashi‐TakagiiD· 1 shared Akinobu MatsumotoiD· 1 shared

Activity by Year

2016-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Gerald R. CrabtreeORCID

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2 papers

Recent·Most cited

Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori, Mikio Hoshino, Akito Nakao, Yasuo Mori, Shigeo Okabe, Masayuki Matsushita, , Michihiro Igarashi

The paper investigates brain pH and lactate levels in animal models of neuropsychiatric disorders, finding decreased pH and increased lactate levels as common features across multiple models.

eLife · Sep 1, 2023Peer-reviewedNeuroscience

Lower brain pH as a shared endophenotype of psychotic disorders

Hideo Hagihara, Vibeke Sorensen Catts, Yuta Katayama, Tsuyoshi Takagi, Freesia L. Huang, Kuo‐Ping Huang, Shunsuke Ishii, Isabella A. Graef, Gerald R. Crabtree, Keiichi I. Nakayama, Cynthia Shannon Weickert, Tsuyoshi Miyakawa

The paper confirms lower brain pH in schizophrenia and bipolar disorder patients and shows it persists in animal models, suggesting it is a pathophysiological feature rather than an artifact.

bioRxiv · Nov 1, 2016 · PreprintNeuroscience