Hideo Hagihara

The paper shows that repetitive neuronal activation induces nuclear reprogramming, leading to cellular maturation state changes with behavioral effects similar to ECT.

The paper investigates brain pH and lactate levels in animal models of neuropsychiatric disorders, finding decreased pH and increased lactate levels as common features across multiple models.

This study shows that lysine lactylation in brain cells is induced by neural excitation and behavioral stimuli, affecting mood-related behaviors.

This study examines the effects of fluoxetine on hippocampal neurons and cortical neurogenesis in marmosets, finding increased immature neuron markers and changes in interneurons.

The paper identifies a shared transcriptomic pseudoimmaturity induced by neural hyperexcitation across multiple neuropsychiatric disorders.

The paper confirms lower brain pH in schizophrenia and bipolar disorder patients and shows it persists in animal models, suggesting it is a pathophysiological feature rather than an artifact.