Identification of a P62-TIF-IA axis that drives nucleolar fusion and the senescence associated secretory phenotype
Hazel C. Thoms, Tyler S. Brant, Katie Duckett, Yizheng Yang, Jinxi Dong, Hongfei Wang, Freya Derby, Oluwatumilara Akeke, Derek A. Mann, Fraser R. Millar, Alex von Kriegsheim, Juan Carlos Acosta, Fiona Oakley, Lesley A. Stark
This study identifies a p62-TIF-IA axis that drives nucleolar fusion and the senescence-associated secretory phenotype (SASP) through ATM-mediated disruption of autophagic degradation.
bioRxiv · Dec 5, 2023 · PreprintMolecular Biology